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Specimen Collection Manual and Test Catalog

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CYCLIC CITRULLINATED PEPTIDE IGG ANTIBODY

Geisinger Epic Procedure Code:  LAB2157    Geisinger Epic ID:  47150

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature specimens stable only 8 hours. Frozen samples are also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <7 U/mL.


Interpretation guide: 

Negative <7 U/mL 
Equivocal 7-10 U/mL 
Positive >10 U/mL 
 


CPT code(s):  86200
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Cyclic Citrullinated Peptide IgG AB


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

CCP, Cyclic Citrullinated Peptide IgG AB, CCP IGG AB, Anti-CCP Ab


Clinical significance: 

A positive CCP antibody, when used in conjunction with other laboratory tests and clinical findings, is an aid in the diagnosis of rheumatoid arthritis. Measurement of both anti-CCP and Rheumatoid Factor are recommended for initial evaluation of potential RA.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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