Specimen Collection Manual and Test Catalog

5x5 mm (2x3mm min) POC or tissue collected in a sterile container in Hanks', Ringer's solution.

Collect in sterile specimen container with Hanks' solution. Patient clinical history and reason for referral are required with test order.

Room temperature.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject

Room temperature: Preferred  Refrigerated: Acceptable  Frozen: Unacceptable

Frozen specimen unacceptable. Formalin-fixed specimens unacceptable.

Interpretive report.

Chromosome Analysis, POC Tissue - Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable.

Submitted placental and/or fetal tissue is cultured. When available, at least 20 G-banded metaphases are examined microscopically for numerical and structural abnormalities and representative metaphases (minimum of 2) are karyotyped.

Products of Conception Analysis, Quest test code 14593, Cytology study-tissue, TISCR

This test is useful to determine cause of miscarriage and recurrence potential.