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Specimen Collection Manual and Test Catalog

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COMPLEMENT C4

Geisinger Epic Procedure Code:  LAB2064    Geisinger Epic ID:  14838

SPECIMEN COLLECTION
Specimen type: 

Plasma or Serum


Preferred collection container: 
Specimen required: 

2 mL of serum or plasma; minimum 0.2 mL.


Patient preparation: 

Fasting specimen preferred.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection.


Transport temperature: 

Refrigerated (preferred). Room temperature specimen also acceptable.


Specimen stability: 

Room temperature: 2 days. Refrigerated: 8 days. Frozen: 3 months.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

10-40 mg/dL


CPT code(s):  86160
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Complement C4.


Methodology: 
Immunoturbidity
Synonyms: 

C4


Clinical significance: 

Decreased C4 level is associated with acute systemic lupus erythematosus, glomerulonephritis, immune complex disease, cryoglobulinemia, congenital C4 deficiency and generalized autoimmune disease.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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