Specimen Collection Manual and Test Catalog

1 mL (minimum 0.5 mL) aliquot of serum AND 2 mL (minimum 1 mL) CSF

BOTH serum AND CSF required. The collection date and time is preferred to be the same for both specimens (maximum 48-hour duration between CSF and serum draw times). Both CSF and serum must be sent for calculation of synthesis rate by nephelometry. CSF must be crystalline clear. Light, moderate, or grossly hemolyzed CSF samples will not be accepted. Serum separator tubes also acceptable

Refrigerate CSF specimens. Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s).

Transport both specimens refrigerated (cold packs) in the same shipping container.

Room Temperature: 8 hours. Refrigerated: 1 week. Frozen: 3 months.

Received room temperature. Hemolysis. Xanthochromia/RBCs/hemolysis in CSF.

The IgG Synthesis Rate, CSF, and IgG Index, CSF, are two formulae for estimating the amount of IgG produced in the central nervous system.

IGG synthesis rate.

IGG SYNTHESIS RATE, Quest test code 7558, CSFIGS

Evidence of increased synthesis of IgG in CSF provides support for the diagnosis of multiple sclerosis.