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Specimen Collection Manual and Test Catalog

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DIGOXIN LEVEL

Geisinger Epic Procedure Code:  LAB2183    Geisinger Epic ID:  6345

SPECIMEN COLLECTION
Specimen type: 

Serum or plasma


Preferred collection container: 
Specimen required: 

2 mL serum or plasma; minimum 0.2 mL.


Patient preparation: 

Specimen should be drawn as a trough level just prior to the next dose or 8-12 hours after the last dose. In patients with renal impairment, specimen should be drawn as a trough level just prior to the next dose or 12-24 hours after the last dose. Patient cannot be on Digibind.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection.


Transport temperature: 

Refrigerated (preferred) or frozen.


Specimen stability: 

Refrigerated: 1 day. Frozen: 2 weeks.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Interpretation guide: 

Recommended trough therapeutic ranges: 
Heart failure: 0.5 to 0.8 ng/mL 
Atrial fibrillation: 0.5 to 1.1 ng/mL


Critical values/courtesy alerts: 
Greater than or equal to 2.5 ng/mL
CPT code(s):  80162
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Digoxin.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

LANOXIN, DIG, DIGITEK


Clinical significance: 

Digoxin is a cardiac glycoside derived from the digitalis plant. It is used to treat congestive heart failure and arterial dysrhythmias. Digoxin levels are monitored to assure adequate therapeutic levels are acheived and to avoid toxicity.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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