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Specimen Collection Manual and Test Catalog

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ITRACONAZOLE

Geisinger Epic Procedure Code:  LAB2559    Geisinger Epic ID:  17674

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

2 mL aliquot of serum; minimum 1 mL. Please submit a separate frozen aliquot for this test. It may not be combined with any other test requiring a frozen aliquot.


Special notes: 

Serum separator tubes are not acceptable.



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge 10 minutes at 3000 rpm.


Transport temperature: 

Frozen.


Specimen stability: 

Room Temperature: 72 hours. Refrigerated: 14 days. Frozen: 30 days.


Rejection criteria: 

Serum separator tubes are not acceptable. Specimens not transported frozen are unacceptable.



TEST DETAILS
Reference interval: 

<0.05 mcg/mL


CPT code(s):  80189
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Itraconazole, Hydroxyitraconazole


Methodology: 
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Synonyms: 

Itraconazole Antifungal Level, ITRAC, Quest test code 94092


Clinical significance: 

The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.


Review Date:  11/25/2024

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