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Geisinger Medical Laboratories Test Catalog
PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) ANTIGEN |
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Geisinger Epic Procedure Code: LAB2855
Geisinger Epic ID: 39189
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SPECIMEN COLLECTION |
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Specimen type: |
Citrated plasma | |
Preferred collection container: |
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Specimen required: |
1 mL frozen citrated plasma; minimum 0.5 mL | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Spin down, remove plasma, and spin plasma again. Aliquot into clean tube. Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and ship on dry ice. | |
Transport temperature: |
Frozen | |
Specimen stability: |
Frozen -20°C: 30 days. Frozen -70°C: 1 year. | |
Rejection criteria: |
Specimen not frozen. | |
TEST DETAILS |
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CPT code(s): |
85415 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Enzyme-Linked Immunosorbent Assay (ELISA) |
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Synonyms: |
PAI, PIA-1, plasma activator inhibitor antigen Quest test code 36555 PAIAG
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Clinical significance: |
Increased activity is associated with increased risk of arterial thrombosis, such as with unexplained premature myocardial infarction. As an acute phase reactant, the activity is increased after an acute event. Studies suggest PAI-1 may be a prognostic marker in early stage breast cancer. | |