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Geisinger Medical Laboratories Test Catalog
N-METHYLHISTAMINE, URINE |
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Geisinger Epic Procedure Code: LAB1039
Geisinger Epic ID: 52081
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SPECIMEN COLLECTION |
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Specimen type: |
Random urine | |
Preferred collection container: |
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Specimen required: |
5 mL random urine (no preservative); minimum 3 mL | |
Special notes: |
Collect a random urine specimen within a few hours of symptom onset. No preservative. | |
Patient preparation: |
Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels. | |
| SPECIMEN PROCESSING |
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Transport temperature: |
Refrigerated (cold packs). | |
Specimen stability: |
Room temperature: 14 days. Refrigerated: 28 days. Frozen: 28 days. | |
TEST DETAILS |
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Additional information: |
Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred. See NMH24 /N-Methylhistamine, 24 Hour, Urine. | |
CPT code(s): |
82542, 82570 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Enzymatic Colorimetric Liquid Chromatography Mass Spectrometry (LC/MS) |
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Synonyms: |
Quest test code 39604, N-Methylhist
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Clinical significance: |
Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using random urine specimens. Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis. | |