Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

ANTINUCLEAR ANTIBODY (ANA) SCREEN WITH REFLEXIVE ANTIBODIES QUANT

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1767         Geisinger Epic ID: 39212

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
0.5 mL serum; minimum 0.2 mL

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge and submit 0.5 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. Refrigerated 2-8°C: 4 days (96 hours). Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

TEST DETAILS
Reference interval:
dsDNA: Negative <10 IU/mL
ENA screen: Negative <0.7 Ratio
Interpretation guide:
dsDNA:
    Negative <10 IU/mL
    Equivocal 10-15 IU/mL
    Positive >15 IU/mL
ENA screen:
    Negative <0.7 Ratio
    Equivocal 0.7-1.0 Ratio
    Positive >1.0 Ratio
CPT code(s):
86038
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
dsDNA Ab quantification and ENA Screen. Extractable nuclear antigens (ENA) Screen is based on recombinant U1-RNP (RNP70, A, C) SS-A/Ro, SS-B / La, Jo-1, Scl-70, Centromere B proteins and native purified Sm proteins as antigen. If ENA screen is positive, reflex to antibody testing (SSA/Ro + SSB/La, Sm + RNP, Jo1, Scl70, Centromere).
Methodology:
Enzyme Immunoassay (EIA)
Synonyms:
ANAEIA, ANA, FANA, Fluorescent Antinuclear Antibody
Antinuclear antibody screen, SJOGRENS
ANAAB
Clinical significance:
The presence of ANA antibodies in correlation with clinical findings and other laboratory tests can aid in the diagnosis of certain rheumatic diseases including systemic lupus erythematosus (SLE), Sjogren's syndrome, mixed connective tissue disease, scleroderma, and rheumatoid arthritis. However, a negative result does not rule out systemic rheumatic or other autoimmune disease. If clinically suspected, further evaluation and testing may be necessary.
Doctoral Director(s:)
Hoi-Ying Elsie Yu PhD, DABCC    
Review Date: 09/01/2022

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: 5 days a week
Performed STAT? No
Locations  |    Search  |    Site Map |   Contact Us
©2000-2022 Geisinger Health System.   All rights reserved.