Dr. Jeffrey Kleinberger
Jeffrey Kleinberger, MD, PhD
Anatomic Pathology, Clinical Pathology, Molecular Genetic Pathology
100 North Academy Avenue
Danville, PA 17822
800-695-6491
Dr. Kleinberger is an associate of Geisinger Medical Laboratories at Danville, Pennsylvania,
Dr. Kleinberger received his PhD in molecular medicine and his medical degree from the University of Maryland School of Medicine in Baltimore. He completed residency training in anatomic and clinical pathlogy and a fellowship in molecular genetic pathology at the University of Pittsburgh Medical Center.
Certifications:
Dr. Kleinberger is board-certified in anatomic and clinical pathology and board-eligible in molecular genetic pathology.
Professional Affiliations:
Association for Molecular Pathology
College of American Pathologists
United States and Canadian Academy of Pathology
Research Interests:
Dr. Kleinberger's primary area of interest is in molecular pathology, particularly next-generation sequencing assays, informatics, and diagnostic test development.
Recent Academic Activity
Publications in Peer-Reviewed Journals:
Alsouqi A, Kleinberger J, Werner TS, Awan R, Chopra S, Rea B, Aggarwal N, Yatsenko SA, Farah R, Bailey NG. Novel FIP1L1::KIT fusion in a myeloid neoplasm with eosinophilia, T-lymphoblastic transformation, and dasatinib response. Haematologica. 2023 Nov 1;108(11):3181-3185. PMID: 37102594.
Zhang H, Kleinberger JW, Maloney KA, Guan Y, Mathias TJ, Bisordi K, Streeten EA, Blessing K, Snyder MN, Bromberger LA, Goehringer J, Kimball A, Damcott CM, Taylor CO, Nicholson M, Nwaba D, Palmer K, Sewell D, Ambulos N, Jeng LJB, Shuldiner AR, Levin P, Carey DJ, Pollin TI. Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program. Diabetes Care. 2022 Aug 1;45(8):1799-1806. PMID: 35763601
Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI. Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes Care. 2021 Oct;44(10):2312. PMID: 34362814
Kleinberger JW, Copeland KC, Gandica RG, Haymond MW, Levitsky LL, Linder B, Shuldiner AR, Tollefsen S, White NH, Pollin TI. Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med. 2018 Jun;20(6):583-590. PMID: 29758564.
Kleinberger J, Maloney KA, Pollin TI, Jeng LJ. An openly available online tool for implementing the ACMG/AMP standards and guidelines for the interpretation of sequence variants. Genet Med. 2016 Nov;18(11):1165. PMID: 26986878.
Kleinberger JW, Maloney KA, Pollin TI. The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice. Am J Perinatol. 2016 Nov;33(13):1319-1326. PMID: 27571483.
Abstracts, Posters, and Other Presentations:
Kleinberger JW, Smith K, Wald AI, Nikiforova MN, Singhi AD. Targeted next-generation sequencing of biliary tract specimens from patients with primary sclerosing cholangitis improves the early detection of cholangiocarcinoma. Association for Molecular Pathology Annual Meeting & Expo. Digital experience (Virtual conference). November 16-20, 2021.
Tise CG, Kleinberger JW, Pavlovich MA, Daue ML, Loesch DP, Reid JG, Overton JD, O’Connell JR, Perry JA, Yerges-Armstrong LM, Shuldiner AR, Zaghloul NA. Autism in the Amish: Exome Sequencing Unveils Novel Coding Variant. Western Society for Pediatric Research Meeting. January 24, 2019. Carmel, CA. Journal of Investigative Medicine, 2019 Vol. 67 (1), 238 (abstract #405).
Zhang H, Kleinberger JW, Mathias TJ, Guan Y, Maloney KA, Streeten EA, Blessing K, Snyder MN, Bromberger L, Goehringer J, Kimball A, Damcott CM, Taylor CO, Nicholson M, Nwaba DC, Palmer K, Ambulos N, Jeng LJB, Shuldiner AR, Levin P, Carey DJ, and Pollin TI. The Personalized Diabetes Medicine Program: Identification, diagnosis and treatment of monogenic diabetes.American Society of Human Genetics Annual Meeting. San Diego, CA. October 19, 2018.
Todd J, Kleinberger JW, Srinivasan S, Tollefsen SE, Levitsky LL, Katz LEL, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, Florez JC, Pollin TI. Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration. American Diabetes Association 78th Annual Scientific Sessions. June 2018. Orlando, FL. Diabetes Jul 2018, 67 (Supplement 1) 268-OR; DOI: 10.2337/db18-268-OR
Tise CG, Kleinberger JW, Pavlovich MA, Daue ML, Perry JA, O’Connell JR, Reid JG, Overton JD, Yerges-Armstrong LM, Shuldiner AR, and Zaghloul NA. Autism spectrum disorder in the Amish: Exome sequencing in a founder population unveils novel coding variants. . American Society of Human Genetics Annual Meeting. Orlando, FL. October 17-21, 2017.
Kleinberger JW, Maloney KA, Jeng LJB, Streeten EA, Stein SA, Mohtasebi Y, Guan Y, Overby CL, Mathias TJ, Ambulos N, Sewell D, Tanner K, Damcott CM, Nicholson MJ, Palmer K, O'Connor TD, Horenstein RB, Silver KD, Shuldiner AR, and Pollin TI. The Personalized Diabetes Medicine Program (PDMP) identifies multiple individuals with potentially treatment-altering diagnoses of monogenic diabetes. American Society of Human Genetics Annual Meeting. Vancouver CN. October 19, 2016.
Jeng L, Kleinberger J. An online tool for applying the ABMGG laboratory training program milestones. American Society of Human Genetics Annual Meeting. Vancouver, CN. October 19, 2016.
Textbooks and Book Chapters
Kleinberger JW, Brown K, Silver KD, and Shuldiner AR. “Genetics of Type 2 Diabetes: From Candidate Genes to Genome-Wide Association Analysis.” Principles of Diabetes Mellitus. Ed. Poretsky, L. Springer International Publishing AG 2017. Pgs. 191-214.
Kleinberger JW and Pollin TI. “Sequencing Approaches to Type 2 Diabetes.” The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Ed. Florez JC. Springer International Publishing 2016. Pgs. 111-126.