Dr. Haiyan Liu

Dr. Haiyan LiuHAIYAN LIU, MD
Anatomic Pathology, Clinical Pathology, Cytopathology
Director, Cytopathology Fellowship Program


100 North Academy Avenue
Danville, PA 17822-0131
1 800 695 6491

Dr. Liu is an Associate of Geisinger Medical Laboratories at Geisinger Medical Center in Danville Pennsylvania. She is also the Director of the Cytopathology Fellowship Program.

Education:

She received her MD from Wenzhou Medical College, Zhejiang, P.R. China, in 1983. Dr. Liu completed residency training in OB/GYN and Wenzhou Medical College and fellowship training in the Practical Use of Laparoscope at Shanghai Second Medical School - Xinhua Hospital Department of OB-GYN. She also completed fellowship training in OB/GYN at Beijing OB/GYN Hospital, Beijing, P. R. China. Dr. Liu completed her pathology residency at the Penn State/Milton S. Hershey Medical Center in Hershey, Pennsylvania, and cytopathology fellowship training at Geisinger Medical Center in Danville.

Certifications:

Dr. Liu is board-certified in both anatomic and clinical pathology as well as cytopathology. She specializes in cytopathology, gastrointestinal pathology, thyroid pathology and genitourinary .

Professional Affiliations:

The United States and Canadian Academy of Pathology (USCAP)
American Society of Cytopathology (ASCP)
College of American Pathologists (CAP)
Pennsylvania Association of Pathologists
Pennsylvania Medical Society

Research Interests:

Her research interests include renal pathology.

Publications in Peer-Reviewed Journals:

Luong-Player A, Liu H, Wang HL, Lin F. Immunohistochemical re-evaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues. Am J Clin Pathol.2014; 141:219-225.

Lin F, Shi J, Zhu S, Chen Z, Li A, Chen T, Wang HL, Liu H. Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med.2014; 138:1015-1026.

Liu H, Shi J, Prichard JW, Gong Y, Lin F. Immunohistochemical evaluation of GATA-3 expression in ER-negative breast carcinomas. Am J Clin Pathol.2014; 141:648-655.

Shieh FK, Luong-Player A, Khara HS, Liu H, Lin F, Shellenberger MJ, Johal AS, Diehl DL. Improved endoscopic retrograde cholangiopancreatography brush increases diagnostic yield of malignant biliary strictures. World J Gastrointest Endosc.2014; 6(7):266-333.

Lin F, Liu H. Application of immunohistochemistry in undifferentiated neoplasms/tumor of uncertain origin. Review article. Arch Pathol Lab Med.2014; In press:.

Wilkerson M, Liu H, Lin F, Cheng L. Genitourinary System (Urinary Bladder, Testis, Prostate and Kidney). Review article. Arch Pathol Lab Med.2014; In press:.

Liu H. Application of immunohistochemistry in breast pathology – A Review and Update. Arch Pathol Lab Med.2014; In press:.

Liu H, Lin F. Application of immunohistochemistry in thyroid pathology – A Review and Update. Arch Pathol Lab Med.2014; In press:.

Shi J, Liu H, Wang HL, Prichard JW, Lin F. Diagnostic utility of pVHL, maspin, IMP3, and S100P in adenocarcinoma of the gallbladder. Hum Pathol.2013; 44:503-511.

Liu H, Shi J, Wilkerson M, Yang XJ, Lin F. Immunohistochemical evaluation of ERG expression in various benign and malignant tissues. Ann Clin Lab Sci.2013; 43:3-9.

Liu H, Shi J, Anandan V, Wang HL, Diehl D, Blansfield J, Gerhard G, Lin F. Reevaluation and identification of the best immunohistochemical panel (pVHL, maspin, S100P, IMP-3) for adenocarcinoma of the pancreas. Arch Pathol Lab Med.2012; 136:601-609.

Liu H, Shi J, Wilkerson ML, Lin F . Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues – a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol.2012; 138:57-64.

Timek DT, Shi J, Liu H, Lin F. Arginase-1, HepPar-1, and glypican-3 are the most effective panel of markers in distinguishing hepatocellular carcinoma from metastatic tumor on fine needle aspiration specimens. Am J Clin Pathol.2012; 42(2):109-117.

Liu H, Shi J, Wang HL, Zhang J, Brown RE, Wilkerson M, Lin F. Expression of von Hippel-Lindau Gene Product (pVHL) and S100P in cystic neoplasms of the pancreas – with an implication for their roles in tumorigenesis. Ann Clin Lab Sci.2012; 42(2):109-117.

Abstracts, Posters, and Other Presentations:

Lin F, Shi J, Chen ZM, Liu H. Immunohistochemical evaluation of c-Myc expression in carcinomas from various organs. Presentation CAP Annual Meeting, Chicago, IL, September 7-10, 2014.

Liu H, Okponobi S, Shi J, Lin F. Identification of a useful immunostaining panel in the distinction between esophageal and pancreatic adenocarcinomas. Presentation CAP Annual Meeting, Chicago, IL, September 7-10, 2014.

Liu H, Lin F. Re-evaluation of expression of immunomarkers in lung adenocarcinomas. Presentation CAP Annual Meeting, Chicago, IL, September 7-10, 2014.

Liu H, Lin F. Immunohistochemical evaluation of Ber-EP4, MOC-31, TAG-72, and CEA in various carcinomas. Presentation CAP Annual Meeting, Chicago, IL, September 7-10, 2014.

Lin F, Shahab A, Liu H. Diagnostic utility of cell blocks with immunostains in Papanicolaou tests (liquid-based preparation). Presentation ASC Annual Meeting, Dallas, TX, November 1-17, 2014.

Luong-Player A, Liu H, Wang HL, Lin F. Immunohistochemical re-evaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Meng X, Liu H, Lin F. Immunohistochemical evaluation of hepatocyte nuclear factor 1B (HNF-1B) expression in tumors from various organs. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Meng X, Lin F, Liu H. Analysis of the atypia of undetermined significance/follicular lesion of undetermined significant (AUS/FLUS) category – experience from 1,366 thyroid fine needle aspiration biopsy (FNA) cases. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Chen ZM, Zhu S, Liu H, Lin F. Loss expression of CDX2 and CK20 in medullary carcinoma of the colon is associated with poor survival. Presentation CAP Annual Meeting, Orlando, FL, October 13-16, 2013.

Shahab A, Liu H, Lin F. Uroplakin II is a useful immunomarker for identification of urothelial carcinomas. Presentation USCAP Annual Meeting, San Diego, CA, March 1-7, 2014.

Lin F, Shi J, Liu H. RNA in situ hybridization is a more sensitive method than immunohistochemistry in detection of napsin A expression in lung adenocarcinomas. Presentation USCAP Annual Meeting, San Diego, CA, March 1-7, 2014.

Liu H, Shi J, Prichard J, Lin F. TROP-2 is a potential novel immunomarker for identification of papillary thyroid carcinomas. Presentation USCAP Annual Meeting, San Diego, CA, March 1-7, 2014.

Chen ZM, Liu H, Lin F. Loss of PAX2 nuclear expression: a useful diagnostic feature for in situ and invasive endocervical adenocarcinoma. Presentation USCAP Annual Meeting, San Diego, CA, March 1-7, 2014.

Liu H, Yin H, Lin F. Re-evaluation of immunohistochemical markers in endometrial adenocarcinomas. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Liu H, Shi J, Wilkerson M, Yang Ximing, Lin F. Evaluation of ERG expression in tumors from various organs. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Liu H, Prichard J, Lin F. Identification of an effective immunohistochemical panel in distinction of breast carcinoma from endometrial adenocarcinoma. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Lin F, Shi J, Wilkerson M, Liu H. Evaluation of GATA3 expression in tumors from various organs. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Timek D, Shi J, Liu H, Lin F. Arginase 1 is a sensitive and specific marker for distinguishing hepatocellular carcinoma from metastatic tumor. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Lin F, Deng H, Kaspar H, Liu H. Immunohistochemical evaluation of microsatellite instability markers in common gynecological carcinomas. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Lin F, Zhu S. Deng H, Liu H. Identification of an effective immunohistochemical panel in distinction of breast carcinoma from lung adenocarcinoma. Abstract 2012 USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Lin F, Prichard J, Zhang X, Liu H. Identification of an effective immunohistochemical panel in distinction of breast carcinoma from ovarian serous carcinoma. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Zhu S, Zhang K, Liu H, Wilkerson M, Lin F. Comparison of expression of Napsin A with polyclonal and monoclonal antibodies in tumors of various organs. Poster presentation USCAP Annual Meeting, Vancouver, Canada, March 17-23, 2012.

Lin F, Deng H, Kaspar H, Prichard J, Liu H. Immunohistochemical evaluation of microsatellite instability (MSI) markers in common gynecological carcinomas. Poster Presentation CAP Annual Meeting , San Diego, CA, September 9-12, 2012.

Liu H, Shi S, Lin F. Identification of an effective immunohistochemical panel for distinguishing Merkel cell carcinoma from pulmonary small cell carcinoma. Poster Presentation CAP Annual Meeting , San Diego, CA, September 9-12, 2012.

Liu H, Wilkerson M, Lin F. Identification of an effective immunohistochemical panel in differentiating seminal vesicles from prostatic adenocarcinoma. Poster Presentation CAP Annual Meeting , San Diego, CA, September 9-12, 2012.

Liu H, Shi J, Wang HL, Lin F. Identification of effective immunohistochemical panels for distinguishing pancreatic endocrine neoplasms from neuroendocrine neoplasms of other organs. Poster Presentation CAP Annual Meeting , San Diego, CA, September 9-12, 2012.

Lin F, Liu H. Mucin-producing neoplasms of the pancreas – cytologic features, limitations and pitfalls on FNA samples. Poster Presentation ASC Annual Meeting , Orlando, FL, November 2012.

Liu H, Shi J, Prichard JW, Yun G, Lin F. Immunohistochemical evaluation of TFF1 and TFF3 expression in ER-negative breast carcinomas. Platform Presentation USCAP Annual Meeting , Baltimore, MD, March 2-8, 2013.

Lin F, Shi J, Aihua L, Chen T, Liu H. Stathmin expression in tumors from various organs - a useful biomarker for confirming endocervical adenocarcinoma and cervical squamous intraepithelial lesions. Poster Presentation USCAP Annual Meeting , Baltimore, MD, March 2-8, 2013.

Lin F, Shi J, Wilkerson M, Liu H. SALL4 and PAX8 expression in carcinomas from various organs. Poster Presentation USCAP Annual Meeting , Baltimore, MD, March 2-8, 2013.

Liu H, Shi J, Lin F. TROP2 expression in various tumors – a potential diagnostic marker for papillary thyroid carcinoma. Poster Presentation USCAP Annual Meeting , Baltimore, MD, March 2-8, 2013.

Shieh FK, Luong-Player A, Liu H, Lin F, Shellenberger M, Inverso N, Johal AS, Diehl D. Improved ERCP cytology brush design and standardized specimen handling yields more tissue and gives higher diagnostic sensitivity in the diagnosis of malignant biliary strictures. Presentation ASCO Annual Meeting, San Francisco, CA, May 2013.

Zhang K, Liu H, Zhu S, Wilkerson M, Lin F. Expression of Napsin A in carcinomas from various organs. Poster Presentation USCAP, San Antonio, Texas, February 26-March 40, 2011.

Liu H. Re-evaluation of expression of MUC1, MUC2, MUC4, MUC5AC, and MUC6 in. Poster Presentation CAP Annual Meeting, Grapevine, TX, September 11-14, 2011.

Liu H, Shi J, Xu Y, Zhang K, Kaspar H, Lin F. Reevaluation of diagnostic value of p120 catenin in differentiating lobular carcinoma from low-grade ductal carcinoma of the breast. Poster Annual CAP Meeteing, Washington, DC, October 2009.

Kaspar H, Lin F, Liu H, MD, Wilkerson M. The value of using p16 immunohistochemical staining in the diagnosis of the limited endocervical samples with tiny hypercellular columnar cell tissue fragments. Poster USCAP Annual Meeting, Chicago, IL, October 2009.

Lin F, Liu H, J Shi, Wilkerson M, Y Huang, Meschter S, Dupree W. Immunohistochemical Detection of p16/ProEXC on Screening Squamous Intraepithelial Lesions in Liquid-Based Cytology Specimens on Cell Block Sections. Presentation American Society of Cytopathology Annual Meeting, Houston, TX, , November 2-6, 2007.

Liu H ,Jianhui Shi, Jun Zhang, Prichard JW, Dupree W, Lin F. The von Hippel-Lindau gene product (pVHL): A diagnostic marker for clear cell carcinoma of the ovary and uterus. Abstract USCAP Meeting, Denver, CO, March 1-7,2008.

Lin F,Jian Shi, Jun Zhang, Liu H, Robert E. Brown, Hanlin Wang. Loss of Expression of von Hipple-Lindau Gene Product (pVHL) and S100P in Cystic Neoplasms of the Pancreas – With an Implication for Their Roles in Tumorigenesis. . Abstract USCAP Meeting, Denver, CO, March 1-7,2008.

Jianhui Shi, Liu H, Wilkerson M, Lin F. ProExC is a better immunohistochemical marker in differentiating between non-invasive low-grade and high-grade papillary urothelial carcinomas. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Shi J, Liu H, Hin W, Lin F. Loss of or reduced expression of von Hippe-lLindau gene product (pVHL) in moderately and poorly differentiated neuroendocrine carcinoma of the lung – a possible role in carcinogenesis. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Liu H, Shi J, Meschter S, Lin F. Loss of reduced expression of the von Hipple-Linadu gene product (pVHL) in malignant salivary epithelial neoplasms – with an implication of its role in tumorigenesis. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Liu H, Shi J, Lin F. Immunodetection of p16/ProExC in liquid-based cytology specimens on cell block sections –To search for a better way on screening of Pap smears. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

PL Zhang, Zhang K, Dorion RP, Liu H, Lin F. Calretinin is a valid marker to assist diagnosis of Hirschsprung disease in rectal suction biopsies without use of acetylcholinesterase staining. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Textbook Chapters

Lin F, Liu H. Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens. In Lin F, Prichard JW, Liu H, Wilkeson M, Chen ZM, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2014, In press.

Liu H, Wilkerson M, Lin F. Thyroid, parathyroid, and adrenal gland. In Lin F, Prichard JW, Liu H, Wilkeson M, Chen ZM, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2014, In press.

Liu H. Breast. In Lin F, Prichard JW, Liu H, Wilkeson M, Chen ZM, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2014, In press.

Wilkerson M, Lin F, Liu H. Kidney, bladder and prostate. In Lin F, Prichard JW, Liu H, Wilkeson M, Chen ZM, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2014, In press.

Lin F, Liu H. Unknown Primary/Undifferentiated Neoplasms in Surgical and Cytological Specimens. In Lin F, Prichard JW, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2011, 55-83.

Liu H, Lin F, DeLellis RA. Thyroid and Parathyroid Gland. In Lin F, Prichard JW, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2011, 137-158.

Liu H. Breast. In Lin F, Prichard JW, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2011, 225-247.

Prichard JW, Liu H, Wilkerson ML. Ovary. In Lin F, Prichard JW, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2011, 277-298.

Liu H, Lin F, Zhai Q. Prostate Gland. In Lin F, Prichard JW, eds. Handbook of Practical Immunohistochemistry: Frequently Asked Questions. Springer, New York, 2011, 299-319.