Dr. Kai Zhang

Kai Zhang, MD, FCAP
Anatomic, Clinical and Hematopathology
Medical Director, Flow Cytometry

100 North Academy Avenue
Danville, PA 17822-0131
1 800 695 6491

Dr. Zhang is an Associate of Geisinger Medical Laboratories at Geisinger Medical Center, where he serves as the Medical Director of the Flow Cytometry Laboratory.

Education:

Dr. Zhang received his MD from Fujian Medical University, China. He received hematopathology fellowship training at the University of Alabama in Birmingham and pathology residency training at Western Reserve Healthcare in Ohio.

Certifications:

He is board certified in anatomic, clinical, and hematopathology. He specializes in , hematopathology, and immunopathology/flow cytometry, head and neck pathology, gastrointestinal pathology, liver and thoracic pathology.

Professional Affiliations:

College of American Pathologists (CAP)
Society of Hematopathology (SH)
Clinical Cytometry Society (CCS)
United States and Canadian Academy of Pathology (USCAP)

Research interests:

Surgical pathology, hematopathology, head and neck, gastrointestinal, liver, thyroid, and thoracic pathology and immunopathology/flow .

Publications in Peer-Reviewed Journals:

Roden AC, Aubery MC, Zhang K, Brady JO, Levin D, Dogan A, Yi ES. Nodular pulmonary amyloidosis of senile transthyretin (ATTR)-type: A unique case confirmed by immunohistochemistry, mass spectrometery and genetic study. Human Pathol 41. 1040-1045, 2010.

Sundaram S and Zhang K. Epstein-Barr virus positive B-cell lymphoproliferative disorder/polymorphic B-cell lymphoma of the urinary bladder: A case report with review of literature. Indian Journal of Urology Jan-March 2009. 129-131, 2009.

Zanetto U, Huang Y, Dong H, Zhang K, Narbaitz M, Sapia S, Kostopoulos I, Liu H, Du MQ, Bacon CM. Mantle cell lymphoma with aberrant expression of CD10. Histopathology June 2008. E Pub Ahead of Print, 2008.

Zhang X, Kryston JJ, Michalak WA, Zhang K, Lin F, Schuerch C. Histiocytic sarcoma in the small intestine: A case report with flow cytometry study and review of the literature. Pathology Research and Practice 204. 763-770, 2008.

Zhang K, Prichard JW, Yoder S, Jitakshi D, Lin F. Utility of SKP2 and MIB-1 in grading follicular lymphoma using quantitative imaging analysis. Human Pathol 38. 878-882, 2007.

Herling M, Jones D, Zhang K. CD4+/CD56+ hematodermic tumor: the features of an evolving entity and its relationship to dendritic cells. (Case contributor by Zhang K. pp. 689-690). Am J Clin Pathol 127. 687-700, 2007.

Zhang K, Prichard JW, Brown RE. Blastic Natural Killer (NK) Cell Leukemia (Agranular CD4+CD56+ Leukemia). Ann Clin Lab Sci 36. 212-215, 2006.

Lin F, Zhang K, Quiery AT,Prichard J, Schuerch C. Plasmablastic lymphoma of the cervical lymph node in an HIV-negative patient – A case report and review of the literature. Arch Pathol Lab Med 128. 581-584, 2004.

Phan SH, Zhang K, Zhang HY, Gharaee-Kermani M: The myofibroblasts as an inflammatory cell in pulmonary fibrosis. 1999, Curr Top Pathol 93: 173-182

Zhang, K, Gharaee-Kermani M, McGarry B, Remick R and Phan S: Role of tumor necrosis factor a (TNFa)-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. 1997, J Immuno 158:954-959.

Zhang, K and Phan SH: Cytokines and pulmonary fibrosis. 1996, J Biol Signal 5:232-239.

Zhang HY, Gharaee-Kermani M, Zhang K, Karmiol S and Phan SH: Lung fibrobIast a-smooth muscle actin expression and contractile phenotype in bleomycin -induced pulmonary fibrosis. 1996, Am J Pathol 148:527-537.

Zhang K, Flanders KC and Phan SH: Cellular localization of transforming growth factor b expression in bleomycin-induced pulmonary fibrosis. 1995, Am J Pathol 147:352-361.

Zhang K, Garner W, Cohen L, Rodriquez J and Phan SH: Increased type I and type III collagen and TGF-b1 m RNA and protein in hypertrophic burn scar.1995, J Invest Dermatol 104: 750-754.

Smith RE, Strieter RM, Zhang K, Phan SH, Standiford TJ, Lukacs NW and Kunkel SL: A role for C-C chemokines in fibrotic lung disease. 1994, J Leuko Biol 57: 782-787.

Zhang K, Gharaee-Kermani M, Jones ML, Warren JS and Phan SH: Monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. 1994, J Immunol 128: 487

Zhang K, Rekhter MD, Gordon D and Phan SH: Myofibroblasts in the lung and their Roles
in Collagen gene expression in a model of pulmonary fibrosis. 1994, Am J Pathol 145: 114.

Zhang K, Gharaee-Kermani M, McGarry B and Phan SH: In situhybridization analysis of rat a(1) and a2(1) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection, 1994, Lab Invest 70:192.

Rekhter MD, Zhang K, Narayanan AS, Phan SH, Schork MA and Gorden D: Type I collagen gene expression in human atherosclerosis, localization to specific plaque regions. 1993, Am J Pathol 143: 163.

Zhang K, Kulig E, Jin L and Lloyd RV: Effects of estrogen and epidermal growth factor on prolactin and Pit-1 mRNAs in GH3 cells. 1993, Pro Soc Exp Biol Med 202: 193.

Other Publications:

Zhang K, Lin F, Shi J, et.al. Expression of Angiostatin Receptor Annexin II in Lung Squamous Cell Carcinoma: A Potential New Therapeutic Target. Arch Pathol Lab Med 132, 284-285, 2008.

Zhang K , Prichard JW, Lin F. Utility of Skp-2 and MIB-1 in Grading Follicular Lymphoma Using Quantitative Image Analysis. Modern Pathol 18, A153, 2004.

Presentations:

Zhang K, Zhang X, Schuerch C, Harrison H. . Dual Expression of CD38 and FMC-7 on CD5+, CD23-/+ (low) Monotypic B-Lymphoid Population Is Highly Predictive of Mantle Cell Lymphoma. Abstract 24th Annual Meeting of Clinical Flow Cytometry, Jacksonville, FL, October 16-21, 2009.

Zhang K, Boctor F. . Plasmablastic lymphoma with unusual high M-component; EBV+ in HIV-positive patient.. Oral Presentation 2009 Society of Hematopathology and European Association of Haematopathology (SH/EAHP) workshop, Cleveland, OH, September 24-26, 2009.

Liu H, Shi J, Xu Y, Zhang K, Kaspar H, Lin F. Reevaluation of diagnostic value of p120 catenin in differentiating lobular carcinoma from low-grade ductal carcinoma of the breast. Poster Annual CAP Meeteing, Washington, DC, October 2009.

Zhang K, J. Shi, Lin F. Expression of Bmi-1in various types of myelodysplastic syndrome (MDS) and with implication of its role in pathogenesis. Abstract XIV meeting of the European Association for Haematopathology, Bordeaux, France, September 20-25, 2008.

Lin F, Liu H, Dorion RP, Zhang K, Pellitteri PK, Schuerch C, Wilkerson M, Meschter S Wilkerson M, Meschter S. Comparison of clinicopathologic features, preoperative fine needle aspiration, and expression of immunohistochemical markers in thyroid papillary microcarcinoma and thyroid papillary carcinoma. Poster Presentation USCAP Meeteing, Boston, March 7-13, 2009.

PL Zhang, Zhang K, Dorion RP, Liu H, Lin F. Calretinin is a valid marker to assist diagnosis of Hirschsprung disease in rectal suction biopsies without use of acetylcholinesterase staining. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Zhang K, Jianhui Shi, Lin F, Nawaz NK, Schuerch C. Expression of Inhibin-alpha in Non-Small Cell Carcinoma of the Lung with a focus on Adenocarcinoma -A Diagnostic Pitfall for Evaluation of Metastatic Pulmonary Carcinoma. Abstract USCAP Meeting, Denver, CO, March 1-7, 2008.

Dorion RP, Jianhui Shi, Zhang K, Schuerch C, Lin F. Utility of S100P in differentiating adenocarcinoma of the lung from papillary carcinoma and follicular carcinoma of the thyroid. Abstract USCAP Meeting, Denver, CO, March 1-7,2008.

Zhang K, Shi J, Lin F. Expression of angiostatin receptor annexin II in lung sqaumous cell carcinoma-a potential new therapeutic target. Presentation Pulmonary pathology society biennial meeting, Santa Fe, NM, June 20-22, 2007.

Zhang K. CD10+ mantle cell lymphoma and aggressive B cell lymphoma (NOS). . Workshop Book European Association for Hematopathology, Vienna, Austria, October 7-12, 2006.

Liu H, Zhang K, Blasick T, Zhang PL, Ahmed M, Lin F. Loss expression of VHL protein in metastatic renal cell carcinoma associated with overexpression of p53. Abstract Modern Pathol 19, 680, 2006.

Zhang K, Yang XJ, Prichard JW, Lun M, Brown RE. Blastic NK cell leukemia. Poster 2004 Clinical Flow Cytometry Meeting, Long Beach, CA, October 15-17,2004.

Zhang K, Prichard JW, Lin F. Utility of Skp-2 and MIB-1 in Grading Follicular Lymphoma Using Quantitative Image Analysis. Poster Presentation USCAP Annual Meeting, San Antonio, TX, 2005.